Article
Role of Bim in regulating CD8+ T-cell responses during chronic viral infection.
Journal of virology - 1 Sept 2006
Grayson Jason M, Weant Ashley E, Holbrook Beth C, Hildeman David
Abstract excerpt
Apoptosis is critical for the development and maintenance of the immune system. The proapoptotic Bcl-2 family member Bim is important for normal immune system homeostasis. Although previous experiments have shown that Bim is critical for the apoptosis of antigen-specific CD8(+) T cells during acute viral infection, the role of Bim during chronic viral infection is unclear. Using lymphocytic choriomeningitis virus...
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