Article
Progression of hypermethylation of the p16(INK4A) gene from normal liver to nontumorous liver and hepatocellular carcinoma: an evaluation using quantitative PCR analysis.
Digestive diseases and sciences - 1 Jan 2009
Kurita So, Ohkoshi Shogo, Yano Masahiko, Yamazaki Kazuhide, Suzuki Kenta, Aoki Yo-hei, Matsuda Yasunobu, Wakai Toshifumi, Shirai Yoshio, Ichida Takafumi, Aoyagi Yutaka
Abstract excerpt
The aim of this study was to determine to what extent hypermethylation of the p16(INK4A) (p16) gene promoter is increased in nontumorous liver tissues compared with in normal liver, using two quantitative methylation-specific polymerase chain reaction (MS-PCR) methods and a bisulfite sequencing method. Methylation of the p16 gene was detected more frequently in nontumorous liver than in normal liver using the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.