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Article

Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas

16 Jul 2008

Abstract excerpt

Hepatocellular carcinoma (HCC) most commonly arises from chronic inflammation due to viral infection, as a result of genetic and epigenetic abnormalities. A global picture of epigenetic changes in HCC is lacking. We used methylated CpG island amplification microarrays (MCAMs) to study 6458 CpG islands in HCC and adjacent preneoplastic tissues [chronic hepatitis (CH) or liver cirrhosis (LC)] in comparison with...

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PMID: 18632756
DOI: 10.1093/carcin/bgn170

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