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Article

Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture.

Oncogene - 5 Feb 2009

Hoskins E E, Morris T A, Higginbotham J M, Spardy N, Cha E, Kelly P, Williams D A, Wikenheiser-Brokamp K A, Duensing S, Wells S I

Abstract excerpt

Fanconi anemia (FA) is a recessive genome instability syndrome characterized by heightened cellular sensitivity to DNA damage, aplastic anemia and cancer susceptibility. Leukemias and squamous cell carcinomas (SCCs) are the most predominant FA-associated cancers, with the latter exhibiting markedly early disease onset and aggressiveness. Although studies of hematopoietic cells derived from FA patients have...

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Share to Antibiotics, Antineoplastic
Share to Cell Transformation, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group A Protein

Share to Human papillomavirus 18

Share to Keratinocytes

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Share to Oncogene Proteins, Viral

Share to Organ Culture Techniques

Source

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Identifiers

PMID: 19015634
DOI: 10.1038/onc.2008.416
PMCID: PMC2636855

Genes

FANCA
FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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