Article
Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis.
Viruses - 6 Jan 2021
Bedard Mary C, Brusadelli Marion G, Carlile Adrean, Ruiz-Torres Sonya, Lodin Hannah, Lee Denis, Kofron Matthew, Lambert Paul F, Lane Adam, Ameziane Najim, Bahassi El Mustapha, Wikenheiser-Brokamp Kathryn A, de Alarcon Alessandro, Smith David F, Wells Susanne I
Abstract excerpt
Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is driven by human papillomavirus (HPV) low-risk strains and is associated with significant morbidity. While previous studies of 2D cultures have shed light on disease pathogenesis and demonstrated the utility of personalized medicine approaches, monolayer cultures lack the 3D tissue architecture and physiology of stratified, sequentially differentiated...
Topics
- Alphapapillomavirus
- Epithelial Cells
- Humans
- Organ Culture Techniques
- Papillomavirus Infections
- Phenotype
- RNA, Viral
- Real-Time Polymerase Chain Reaction
- Respiratory Tract Infections
- Risk Factors