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Article

NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

12 Oct 2020

Abstract excerpt

Cancer associated fibroblasts (CAFs) are a key component of the tumor microenvironment. Genomic alterations in these cells remain a point of contention. We report that CAFs from skin squamous cell carcinomas (SCCs) display chromosomal alterations, with heterogeneous NOTCH1 gene amplification and overexpression that also occur, to a lesser extent, in dermal fibroblasts of apparently unaffected skin. The fraction...

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PMID: 33046701
DOI: 10.1038/s41467-020-18919-2

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