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Article

Down-regulation of a kinase defective PKC-alpha.

FEBS letters - 17 Jun 1991

Pears C, Parker P J

Abstract excerpt

A kinase defective mutant of PKC-alpha down-regulates in response to phorbol esters as effectively as the wild-type protein when introduced into COS-1 cells. This demonstrates that intramolecular autophosphorylation is not a prerequisite for down-regulation.

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Source

Identifiers

PMID: 2060619
DOI: 10.1016/0014-5793(91)80776-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Down-regulation of a kinase defective PKC-alpha.PMID 2060619Read ↗

A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation.Semantic proximity Read ↗

Downregulation of protein kinase C-gamma is independent of a functional kinase domain.Semantic proximity Read ↗

Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts.Semantic proximity Read ↗

Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form.Semantic proximity Read ↗

Partial down-regulation of protein kinase C reverses the growth inhibitory effect of phorbol esters on HepG2 cells.Semantic proximity Read ↗

The broad specificity of dominant inhibitory protein kinase C mutants infers a common step in phosphorylation.Semantic proximity Read ↗

A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.Semantic proximity Read ↗

Yeast phenotype classifies mammalian protein kinase C cDNA mutants.Semantic proximity Read ↗

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