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Article

Down-regulation of a kinase defective PKC-alpha.

FEBS letters - 17 Jun 1991

Pears C, Parker P J

Abstract excerpt

A kinase defective mutant of PKC-alpha down-regulates in response to phorbol esters as effectively as the wild-type protein when introduced into COS-1 cells. This demonstrates that intramolecular autophosphorylation is not a prerequisite for down-regulation.

Topics

Animals
Blotting, Western
Cell Line
Down-Regulation
Kidney
Kinetics
Mutation
Protein Kinase C
Tetradecanoylphorbol Acetate

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2060619
DOI: 10.1016/0014-5793(91)80776-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2060619-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Down-regulation of a kinase defective PKC-alpha.PMID 2060619Read ↗

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