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Article

Myosin, transgelin, and myosin light chain kinase: expression and function in asthma.

American journal of respiratory and critical care medicine - 1 Feb 2009

Léguillette Renaud, Laviolette Michel, Bergeron Celine, Zitouni Nedjma, Kogut Paul, Solway Julian, Kachmar Linda, Hamid Qutayba, Lauzon Anne-Marie

Abstract excerpt

RATIONALE: Airway smooth muscle (SM) of patients with asthma exhibits a greater velocity of shortening (Vmax) than that of normal subjects, and this is thought to contribute to airway hyperresponsiveness. A greater Vmax can result from increased myosin activation. This has been reported in sensitized human airway SM and in models of asthma. A faster Vmax can also result from the expression of specific contractile...

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Identifiers

PMID: 19011151
DOI: 10.1164/rccm.200609-1367OC
PMCID: PMC2633053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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