Article
Repeated allergen inhalation induces phenotypic modulation of smooth muscle in bronchioles of sensitized rats.
American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2003
Moir Lyn M, Leung Sum-Yee, Eynott Paul R, McVicker Clare G, Ward Jeremy P T, Chung K Fan, Hirst Stuart J
Abstract excerpt
Repeated ovalbumin (OA) or saline exposure of sensitized Brown Norway rats was examined on agonist reactivity, airway smooth muscle (ASM) content, and contractile protein expression in small bronchioles at 24 h, 7 days, and 35 days after challenge. OA increased ASM content (P < 0.05 vs. saline) at 24 h, which resolved by 7 days. Maximum developed tension (T(max)) to carbachol, KCl, and 4-beta-phorbol...
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