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Article

Heterogeneity amongst 5-HT₃ receptor subunits: is this significant?

Current molecular medicine - 1 Feb 2011

Yaakob N, Malone D T, Exintaris B, Irving H R

Abstract excerpt

The serotonin 3 (5-HT₃) receptor is a ligand gated ion channel unlike the other 5-HT receptors which are G protein coupled receptors. The functional 5-HT₃ receptor forms a pentamer of five symmetrically arranged subunits surrounding a central pore. The 5-HT(3A) subunit was first identified at a molecular level and can form functional homomers or heteromers with the 5-HT(3B) subunit. Recently, three new 5-HT₃...

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PMID: 21189117
DOI: 10.2174/156652411794474392

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