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Article

Immunoglobulin class switch recombination: study through human natural mutants.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 12 Mar 2009

Durandy Anne

Abstract excerpt

Immunoglobulin class switch recombination deficiencies in humans are exquisite models to analyse the mechanisms of class switch recombination (CSR). Besides defects in CD40L/CD40 interaction, others result from an intrinsic B-cell deficiency. The recent elucidation of the molecular basis of some of them has made it possible to delineate the molecular events involved in antibody maturation. Activation-induced...

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Share to Antibodies
Share to CD40 Antigens
Share to CD40 Ligand

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to DNA Breaks, Double-Stranded

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Source

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Identifiers

PMID: 19008192
DOI: 10.1098/rstb.2008.0210
PMCID: PMC2660924

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