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Article

Human genetic defects in class-switch recombination (hyper-IgM syndromes).

Current opinion in immunology - 1 Oct 2001

Durandy A, Honjo T

Abstract excerpt

Several genetic defects in class-switch recombination, leading to hyper-IgM syndromes, have been recently described in humans. Besides the well-known role of interaction between CD40-ligand and CD40, these pathological conditions definitively demonstrate the requirement of CD40-mediated NF-kappaB activation and the essential role of a newly described molecule, activation-induced cytidine deaminase (AID), in B...

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Source

Identifiers

PMID: 11544001
DOI: 10.1016/s0952-7915(00)00256-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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