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Article

Differential functions of the Apoer2 intracellular domain in selenium uptake and cell signaling.

Biological chemistry - 1 Jan 2009

Masiulis Irene, Quill Timothy A, Burk Raymond F, Herz Joachim

Abstract excerpt

Apolipoprotein E receptor 2 (Apoer2) is a multifunctional transport and signaling receptor that regulates the uptake of selenium into the mouse brain and testis through endocytosis of selenoprotein P (Sepp1). Mice deficient in Apoer2 or Sepp1 are infertile, with kinked and hypomotile spermatozoa. They also develop severe neurological defects on a low selenium diet, due to a profound impairment of selenium uptake....

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Identifiers

PMID: 19007311
DOI: 10.1515/BC.2009.011
PMCID: PMC2642607

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