Article
Mycobacterium tuberculosis phoP mutant: lipoarabinomannan molecular structure.
Microbiology (Reading, England) - 1 Oct 2002
Ludwiczak Pascal, Gilleron Martine, Bordat Yann, Martin Carlos, Gicquel Brigitte, Puzo Germain
Abstract excerpt
Mycobacterium tuberculosis encodes two-component signal systems. Recently, it was established that the viability of the M. tuberculosis phoP mutant is attenuated in the mouse, suggesting the requirement of the phoP gene for M. tuberculosis intracellular growth. It is now largely acknowledged that M. tuberculosis mannosylated lipoarabinomannans (ManLAM) play a key role in M. tuberculosis intramacrophagic survival...
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