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Article

Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis.

Genes and immunity - 1 Sept 2012

Invernizzi P, Ransom M, Raychaudhuri S, Kosoy R, Lleo A, Shigeta R, Franke A, Bossa F, Amos C I, Gregersen P K, Siminovitch K A, Cusi D, de Bakker P I W, Podda M, Gershwin M E, Seldin M F

Abstract excerpt

Susceptibility to primary biliary cirrhosis (PBC) is strongly associated with human leukocyte antigen (HLA)-region polymorphisms. To determine if associations can be explained by classical HLA determinants, we studied Italian, 676 cases and 1440 controls, genotyped with dense single-nucleotide polymorphisms (SNPs) for which classical HLA alleles and amino acids were imputed. Although previous genome-wide...

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Identifiers

PMID: 22573116
DOI: 10.1038/gene.2012.17
PMCID: PMC3423484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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