Article
rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney.
American journal of physiology. Renal physiology - 1 Sept 2002
Fernández Esperanza, Carrascal Montserrat, Rousaud Ferran, Abián Joaquín, Zorzano Antonio, Palacín Manuel, Chillarón Josep
Abstract excerpt
Mutations in the rBAT and b(0,+)AT genes cause type I and non-type I cystinuria, respectively. The disulfide-linked rBAT-b(0,+)AT heterodimer mediates high-affinity transport of cystine and dibasic amino acids (b(0,+)-like activity) in heterologous cell systems. However, the significance of this heterodimer for cystine reabsorption is unknown, as direct evidence for such a complex in vivo is lacking and the...
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