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Article

Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane.

The Journal of biological chemistry - 8 Oct 2004

Li Hong C, Worrell Roger T, Matthews Jeffrey B, Husseinzadeh Holleh, Neumeier Lisa, Petrovic Snezana, Conforti Laura, Soleimani Manoocher

Abstract excerpt

The Na+-HCO3- cotransporter NBC1 is located exclusively on the basolateral membrane and mediates vectorial transport of bicarbonate in a number of epithelia, including kidney and pancreas. To identify the motifs that direct the targeting of kidney NBC1 to basolateral membrane, wild type and various carboxyl-terminally truncated kidney NBC1 mutants were generated, fused translationally in-frame to GFP, and...

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PMID: 15273250
DOI: 10.1074/jbc.M405780200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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