Article
Two hypoxia sensor genes and their association with symptoms of acute mountain sickness in Sherpas.
Aviation, space, and environmental medicine - 1 Nov 2008
Droma Yunden, Ota Masao, Hanaoka Masayuki, Katsuyama Yoshihiko, Basnyat Buddha, Neupane Pritam, Arjyal Amit, Pandit Anil, Sharma Dependra, Ito Michiko, Kubo Keishi
Abstract excerpt
INTRODUCTION: Hypoxia-inducible factor (HIF) and von Hippel-Lindau tumor suppressor protein (VHL) are hypoxia sensors that control cellular responses to hypoxia. Although many Sherpas live at high altitudes for their entire lives, some of them manifest symptoms of acute mountain sickness (AMS) du...
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