Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in hypoxia-inducible factor 1alpha and its possible association with high altitude adaptation in Sherpas.

Medical hypotheses - 1 Sept 2003

Suzuki K, Kizaki T, Hitomi Y, Nukita M, Kimoto K, Miyazawa N, Kobayashi K, Ohnuki Y, Ohno H

Abstract excerpt

Hypoxic stress at high altitude requires adaptations in several physiological functions to ensure the optimal oxygenation of all cells. Several lines of evidence suggested that high-altitude native populations such as Sherpas have been genetically adapted to their stressful environment. We invest...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Altitude
Share to Chromosomes, Human, Pair 14

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dinucleotide Repeats

Share to Hypoxia-Inducible Factor 1

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Introns

Share to Nuclear Proteins

Source

Identifiers

PMID: 12944107
DOI: 10.1016/s0306-9877(03)00178-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12944107-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in hypoxia-inducible factor 1alpha and its possible association with high altitude adaptation in Sherpas.PMID 12944107Read ↗

[Association of polymorphisms of 1772 (C-->T) and 1790 (G-->A) in HIF1A gene with hypoxia adaptation in high altitude in Sherpas].Semantic proximity Read ↗

Genetic variants in EPAS1 contribute to adaptation to high-altitude hypoxia in Sherpas.Semantic proximity Read ↗

A non-synonymous SNP with the allele frequency correlated with the altitude may contribute to the hypoxia adaptation of Tibetan chicken.Semantic proximity Read ↗

Variations in HIF-1α Contributed to High Altitude Hypoxia Adaptation via Affected Oxygen Metabolism in Tibetan SheepSemantic proximity Read ↗

Downregulation of EPAS1 and EGLN1 mRNA Expression Associated With High-Altitude Adaptive Genetic Variants in Sherpa Highlanders.Semantic proximity Read ↗

High-altitude adaptation: Role of genetic and epigenetic factors.Semantic proximity Read ↗

Two hypoxia sensor genes and their association with symptoms of acute mountain sickness in Sherpas.Semantic proximity Read ↗

Genetic contribution of the endothelial nitric oxide synthase gene to high altitude adaptation in sherpas.Semantic proximity Read ↗

[Study of nine single nucleotide polymorphism loci of human HIF1A gene in three Tibetan groups].Semantic proximity Read ↗

Hypoxia-tolerant vascular endothelial growth factor-A (VEGF-A) and the genetic variations of <i>VEGFA</i> in Sherpa highlandersSemantic proximity Read ↗

Yak Response to High-Altitude Hypoxic Stress by Altering mRNA Expression and DNA Methylation of Hypoxia-Inducible FactorsSemantic proximity Read ↗

Population History and Altitude-Related Adaptation in the SherpaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.