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Article

Functional consequences of the human leptin receptor (LEPR) Q223R transversion.

Obesity (Silver Spring, Md.) - 1 Jan 2009

Stratigopoulos George, LeDuc Charles A, Matsuoka Naoki, Gutman Roee, Rausch Richard, Robertson Scott A, Myers Martin G, Chung Wendy K, Chua Streamson C, Leibel Rudolph L

Abstract excerpt

Perturbations in the functional integrity of the leptin axis are obvious candidates for mediation of altered adiposity. In a large number of genetic association studies in humans, the nonconservative LEPR Q223R allele has been inconsistently associated with adiposity. Subtle, long-term effects of such genetic variants can be obscured by effects of the environment and other confounders that render definitive...

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Source

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Identifiers

PMID: 18997673
DOI: 10.1038/oby.2008.489
PMCID: PMC2808713

Genes

LEPR
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Functional consequences of the human leptin receptor (LEPR) Q223R transversion.PMID 18997673Read ↗

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