Article
High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow.
Blood - 5 Mar 2009
Melenhorst J Joseph, Scheinberg Phillip, Chattopadhyay Pratip K, Gostick Emma, Ladell Kristin, Roederer Mario, Hensel Nancy F, Douek Daniel C, Barrett A John, Price David A
Abstract excerpt
The activity of allogeneic CD8(+) T cells specific for leukemia-associated antigens (LAAs) is thought to mediate, at least in part, the curative effects of hematopoietic stem cell transplantation (HSCT) in myeloid malignancies. However, the identity and nature of clinically relevant LAA-specific CD8(+) T-cell populations have proven difficult to define. Here, we used a combination of coreceptor-mutated...
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