Article
Classification of familial amyotrophic lateral sclerosis by family history: effects on frequency of genes mutation.
Journal of neurology, neurosurgery, and psychiatry - 1 Dec 2012
Conte Amelia, Lattante Serena, Luigetti Marco, Del Grande Alessandra, Romano Angela, Marcaccio Alessandro, Marangi Giuseppe, Rossini Paolo Maria, Neri Giovanni, Zollino Marcella, Sabatelli Mario
Abstract excerpt
OBJECTIVE: To classify familial amyotrophic lateral sclerosis (FALS) on the base of family history, and to determine whether frequency of mutations in major amyotrophic lateral sclerosis (ALS) genes varies in different FALS categories. METHODS: Included in the study are 53 FALS families. Patients were classified as definite, probable and possible FALS, according to recently proposed criteria. Seven ALS-associated...
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