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Identity by descent analysis identifies founder events and links SOD1 familial and sporadic ALS cases

7 Aug 2020

Abstract excerpt

Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by the loss of upper and lower motor neurons resulting in paralysis and eventual death. Approximately 10% of ALS cases have a family history of disease, while the remainder present as apparently sporadic cases. Heritability studies suggest a significant genetic component to sporadic ALS, and although most sporadic cases...

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PMID: 32789025
DOI: 10.1038/s41525-020-00139-8

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