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Article

Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1.

Developmental biology - 1 Jan 2009

Himes Ashley D, Raetzman Lori T

Abstract excerpt

In the pituitary, the transition from proliferating progenitor cell into differentiated hormone producing cell is carefully regulated in a time-dependent and spatially-restricted manner. We report that two targets of Notch signaling, Hes1 and Prop1, are needed to maintain progenitors within Rathke's pouch and for the restriction of differentiated cells to the ventral pituitary. We observed ACTH and alphaGSU...

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Identifiers

PMID: 18996108
DOI: 10.1016/j.ydbio.2008.10.010
PMCID: PMC2642967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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