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Article

SOX2 regulates the hypothalamic-pituitary axis at multiple levels

4 Sept 2012

Abstract excerpt

Sex-determining region Y (SRY) box 2 (SOX2) haploinsufficiency causes a form of hypopituitarism in humans that is characterized by gonadotrophin deficiency known as hypogonadotrophic hypogonadism. Here, we conditionally deleted Sox2 in mice to investigate the pathogenesis of hypogonadotrophic hypogonadism. First, we found that absence of SOX2 in the developing Rathke pouch of conditional embryos led to severe...

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PMID: 22945632
DOI: 10.1172/jci64311

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