Article
Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Japanese population.
Annals of the New York Academy of Sciences - 1 Oct 2008
Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Iyo Masaomi, Sora Ichiro, Sekine Yoshimoto, Ozaki Norio, Ujike Hiroshi, Iwata Nakao
Abstract excerpt
Abnormal intracellular signaling molecules in dopamine signal transduction are thought to be associated with the pathophysiology of methamphetamine (METH)-use disorder. A recent study reported that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in dopamine 2 receptor signaling. We therefore analyzed the association between the Par-4 gene (PAWR) and METH-use disorder in a...
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