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Article

Par-4 links dopamine signaling and depression.

Cell - 29 Jul 2005

Park Sang Ki, Nguyen Minh Dang, Fischer André, Luke Margaret Po-Shan, Affar El Bachir, Dieffenbach Paul Brian, Tseng Huang-Chun, Shi Yang, Tsai Li-Huei

Abstract excerpt

Prostate apoptosis response 4 (Par-4) is a leucine zipper containing protein that plays a role in apoptosis. Although Par-4 is expressed in neurons, its physiological role in the nervous system is unknown. Here we identify Par-4 as a regulatory component in dopamine signaling. Par-4 directly interacts with the dopamine D2 receptor (D2DR) via the calmodulin binding motif in the third cytoplasmic loop. Calmodulin...

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Source

Identifiers

PMID: 16051151
DOI: 10.1016/j.cell.2005.05.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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