Article
Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population.
Annals of the New York Academy of Sciences - 1 Oct 2008
Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Iyo Masaomi, Sora Ichiro, Sekine Yoshimoto, Ozaki Norio, Ujike Hiroshi, Iwata Nakao
Abstract excerpt
The mesolimbic system is thought to be involved in the reinforcing action of many addictive drugs and the release of dopamine modulated by neuronal nicotine cholinergic receptors (nAChRs). Several investigations suggested that nAChRs on dopaminergic terminals play an important role in the development of some long-lasting adaptations associated with drug abuse. A majority of high-affinity nicotine binding sites in...
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