The dysfunctional LDL receptor in a monensin-resistant mutant of Chinese hamster ovary cells lacks selected O-linked oligosaccharides.

doi:10.1016/0003-9861(91)90292-q

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Article

The dysfunctional LDL receptor in a monensin-resistant mutant of Chinese hamster ovary cells lacks selected O-linked oligosaccharides.

Archives of biochemistry and biophysics - 1 Feb 1991

Seguchi T, Merkle R K, Ono M, Kuwano M, Cummings R D

Abstract excerpt

The Chinese hamster ovary (CHO) cell line Monr31, which is resistant to the cytotoxic ionophore monensin, produces a receptor for the low density lipoprotein (LDL) that has a lowered binding affinity for LDL and is approximately 5 kDa smaller in size than the receptor from parental CHO cells. It has been proposed that the reduced size and affinity for LDL are associated with a reduced level of O-glycosylation of...

Topics

Acetylgalactosamine
Acetylglucosamine
Animals
Asparagine
Carbohydrate Conformation
Cell Line
Cricetinae
Cricetulus
Drug Resistance
Female
Glycopeptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycosylation

Humans

Monensin

Mutation

Oligosaccharides

Receptors, LDL

Serine

Source

Open in PubMed

Identifiers

PMID: 1899178
DOI: 10.1016/0003-9861(91)90292-q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1899178-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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