Article
Coordinated molecular control of otic capsule differentiation: functional role of Wnt5a signaling and opposition by sfrp3 activity.
Growth factors (Chur, Switzerland) - 1 Dec 2008
Liu Wei, Li Lijun, Li Geming, Garritano Frank, Shanske Alan, Frenz Dorothy A
Abstract excerpt
Wnt proteins constitute one of the major families of secreted ligands that function in developmental signaling, however, little is known of the role of Wnt5a during inner ear development. It is hypothesized that Wnt5a acts as a mediator of chondrogenesis in the developing otic capsule, a cartilaginous structure that surrounds the developing inner ear and presages the formation of the endochondral bony labyrinth....
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