Article
WNT signaling and cartilage: of mice and men.
Calcified tissue international - 1 May 2013
Ma Bin, Landman Ellie B M, Miclea Razvan L, Wit Jan M, Robanus-Maandag Els C, Post Janine N, Karperien Marcel
Abstract excerpt
In adult articular cartilage, the extracellular matrix is maintained by a balance between the degradation and the synthesis of matrix components. Chondrocytes that sparsely reside in the matrix and rarely proliferate are the key cellular mediators for cartilage homeostasis. There are indications for the involvement of the WNT signaling pathway in maintaining articular cartilage. Various WNTs are involved in the...
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