Article
Gata3 is required for early morphogenesis and Fgf10 expression during otic development.
Mechanisms of development - 1 Jun 2006
Lilleväli Kersti, Haugas Maarja, Matilainen Tanja, Pussinen Christel, Karis Alar, Salminen Marjo
Abstract excerpt
Inner ear develops from an induced surface ectoderm placode that invaginates and closes to form the otic vesicle, which then undergoes a complex morphogenetic process to form the membranous labyrinth. Inner ear morphogenesis is severely affected in Gata3 deficient mouse embryos, but the onset and basis of the phenotype has not been known. We show here that Gata3 deficiency leads to severe and unique abnormalities...
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