Spontaneous hyperactivity in mutant mice lacking the NMDA receptor GluRepsilon1 subunit is aggravated during exposure to 0.1 MAC sevoflurane and is preserved after emergence from sevoflurane anaesthesia.

doi:10.1017/S0265021508004626

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Article

Spontaneous hyperactivity in mutant mice lacking the NMDA receptor GluRepsilon1 subunit is aggravated during exposure to 0.1 MAC sevoflurane and is preserved after emergence from sevoflurane anaesthesia.

European journal of anaesthesiology - 1 Dec 2008

Petrenko A B, Kohno T, Wu J, Sakimura K, Baba H

Abstract excerpt

BACKGROUND AND OBJECTIVE: Patients who awake from sevoflurane anaesthesia with symptoms of agitation may have some underlying functional substrate that is sensitive to the low concentrations of anaesthetic encountered during emergence. One candidate for such a substrate could be neurocircuitry implied in the pathophysiology of both agitation and movement disorders with hyperactivity. We postulated that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18990258
DOI: 10.1017/S0265021508004626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.