Additional genetic risk factor for death in children with acute lymphoblastic leukemia: a common polymorphism of the MTHFR gene.

doi:10.1002/pbc.21815

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Article

Additional genetic risk factor for death in children with acute lymphoblastic leukemia: a common polymorphism of the MTHFR gene.

Pediatric blood & cancer - 1 Mar 2009

Pietrzyk Jacek J, Bik-Multanowski Miroslaw, Balwierz Walentyna, Skoczen Szymon, Wojcik Dorota, Chybicka Alicja, Sikorska-Fic Barbara, Matysiak Michal, Szczepanski Tomasz, Sonta-Jakimczyk Danuta, Ploszynska Anna, Balcerska Anna, Mycko Katarzyna, Bodalski Jerzy, Krawczuk-Rybak Maryna, Kowalczyk Jerzy, Koltan Andrzej, Sobol Grazyna, Derwich Katarzyna, Kwinta Przemko

Abstract excerpt

BACKGROUND: The presence of metabolically important genetic polymorphisms may affect treatment efficacy in patients with malignancies. The objective of this prospective multicenter study was to evaluate the role of selected polymorphisms of genes associated with metabolism of chemotherapeutic drugs as prognostic markers in children with acute lymphoblastic leukemia. PROCEDURE: Genotyping for the presence of 7...

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PMID: 18989887
DOI: 10.1002/pbc.21815

Genes

MTHFR

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