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Article

Nonparametric estimation of LOH using Affymetrix SNP genotyping arrays for unpaired samples.

Journal of human genetics - 1 Jan 2008

Huggins Richard, Li Ling-Hui, Lin You-Chin, Yu Alice L, Yang Hsin-Chou

Abstract excerpt

Studies of loss of heterozygosity (LOH) play an important role in cancer research. In this paper, we developed a two-step procedure to examine LOH by comparing unpaired tumour and normal samples. In the first step we determined which chromosomes significantly differ between the two sets of samples by using nonparametric procedures. We then used the biplot data visualisation technique and homozygosity intensity...

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Source

Identifiers

PMID: 18989737
DOI: 10.1007/s10038-008-0340-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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