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Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.

Cancer research - 15 Aug 2006

Calhoun Eric S, Hucl Tomas, Gallmeier Eike, West Kristen M, Arking Dan E, Maitra Anirban, Iacobuzio-Donahue Christine A, Chakravarti Aravinda, Hruban Ralph H, Kern Scott E

Abstract excerpt

Recent advances in oligonucleotide arrays and whole-genome complexity reduction data analysis now permit the evaluation of tens of thousands of single-nucleotide polymorphisms simultaneously for a genome-wide analysis of allelic status. Using these arrays, we created high-resolution allelotype maps of 26 pancreatic cancer cell lines. The areas of heterozygosity implicitly served to reveal regions of allelic loss....

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PMID: 16912165
DOI: 10.1158/0008-5472.CAN-06-0721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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