Article
Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Aug 2004
Li Tao, Ma Xiaohong, Sham Pak C, Sun Xueli, Hu Xun, Wang Qiang, Meng Huaqing, Deng Wei, Liu Xiehe, Murray Robin M, Collier David A
Abstract excerpt
Haploinsufficiency for or mutation in at least one gene from the velocardiofacial syndrome (VCFS) region at chromosome 22q11 is implicated in psychosis. Linkage disequilibrium mapping of the region in patients identified a segment containing two genes, proline dehydrogenase (PRODH) and DGCR6, as candidates [Liu et al., 2002a] and by analysis of additional polymorphisms the PRODH gene was associated with...
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