Genome-based prediction of cross-protective, HLA-DR-presented epitopes as putative vaccine antigens for multiple Bordetella species

Abstract excerpt

ABSTRACT Acellular pertussis vaccines protect against severe pertussis, but vaccine-induced immunity wanes over time. Prior animal studies showed that T-cell responses are integral to long-lasting immunity. Current pertussis vaccines also do not provide considerable protection against other species that cause pertussis-like illness, such as Bordetella parapertussis and Bordetella holmesii . We aimed to identify...

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