Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

doi:10.1128/CVI.00175-07

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Article

Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

Clinical and vaccine immunology : CVI - 1 Oct 2007

Banus Sander, Bottema Renske W B, Siezen Christine L E, Vandebriel Rob J, Reimerink Johan, Mommers Monique, Koppelman Gerard H, Hoebee Barbara, Thijs Carel, Postma Dirkje S, Kimman Tjeerd G, Stelma Foekje F

Abstract excerpt

We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.

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PMID: 17699831
DOI: 10.1128/CVI.00175-07
PMCID: PMC2168111

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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