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Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary

5 Nov 2008

Abstract excerpt

Glycopeptide antibiotics have long served as drugs of last resort for the treatment of antibiotic-resistant gram-positive bacterial infections. Resistance to the clinically relevant glycopeptides, vancomycin and teicoplanin, threatens to undermine the usefulness of this important class of antibiotics. DNA extracted from a geographically diverse collection of soil samples was screened by PCR for the presence of...

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PMID: 18987322
DOI: 10.1073/pnas.0807564105

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