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Article

Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study.

Journal of the American Chemical Society - 31 Dec 2014

Kang Hahk-Soo, Brady Sean F

Abstract excerpt

Sequence-guided mining of metagenomic libraries provides a means of recovering specific natural product gene clusters of interest from the environment. In this study, we use ketosynthase gene (KS) PCR amplicon sequences (sequence tags) to explore the structural and biosynthetic diversities of pentangular polyphenols (PP). In phylogenetic analyses, eDNA-derived sequence tags often fall between closely related...

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Identifiers

PMID: 25521786
DOI: 10.1021/ja510606j
PMCID: PMC4291760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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