Article
Association analysis of a polymorphism of the monoamine oxidase B gene with Parkinson's disease in a Japanese population.
American journal of medical genetics - 18 Dec 1995
Morimoto Y, Murayama N, Kuwano A, Kondo I, Yamashita Y, Mizuno Y
Abstract excerpt
The polymorphic allele of the monoamine oxidase B (MAO-B) gene detected by polymerase chain reaction (PCR) and single-stranded conformation polymorphism (SSCP) was associated with Parkinson's disease (PD) in Caucasians. We characterized this polymorphic allele, allele 1, of the MAO-B gene using direct sequencing of PCR products. A single DNA substitution (G-A), resulting gain of Mae III restriction site was...
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