Article
Asparagine markedly induces the expression of ornithine decarboxylase gene in transformed mammalian cells but not in their untransformed counterparts.
Cancer letters - 28 Oct 1994
Chen Z P, Chen K Y
Abstract excerpt
We have previously shown that asparagine alone induces a 10-15-fold increase in ornithine decarboxylase (ODC) mRNA level in DF-40 mouse neuroblastoma cells. The induction is due to an accumulation of ODC mRNA through a post-transcriptional stabilization mechanism (Chen, Z.P. and Chen, K.Y. (1992)...
Topics
- 3T3 Cells
- Animals
- Asparagine
- Blotting, Southern
- Cell Transformation, Neoplastic
- Enzyme Induction
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- Mice
- Oncogenes
- Ornithine Decarboxylase
- Phenotype
- RNA, Messenger