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Mechanistic insight into the regulation of virulence factor type 1 pili in pathogenic <i>E. coli</i> by rhomboid protease GlpG

2025-09-09

Abstract excerpt

With the rise in antimicrobial resistance, understanding the virulence factors utilized by pathogenic E. coli is essential for the development of alternative therapeutics. While previous work has shown that disruption of the E. coli rhomboid protease gene glpG leads to defects in bacterial colonization, here we provide mechanistic insight into the loss of fitness. We show GlpG is essential for the assembly of t...

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Literature Corpus work
c28e0950-36ae-5f14-8add-f6076a56e546
DOI
10.1101/2025.09.09.675128
Open publication

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Mechanistic insight into the regulation of virulence factor type 1 pili in pathogenic <i>E. coli</i> by rhomboid protease GlpGDOI 10.1101/2025.09.09.675128
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