Article
Type 2 diabetes susceptibility genes on chromosome 1q21-24.
Annals of human genetics - 1 Mar 2008
Hasstedt S J, Chu W S, Das S K, Wang H, Elbein S C
Abstract excerpt
Type 2 diabetes (T2D) has been linked to chromosome 1q21-24 in multiple samples, including a Utah family sample. Variants in 13 of the numerous candidate genes in the 1q region were tested for association with T2D in a Utah case-control sample. The most promising, 19 variants in 6 candidates, were genotyped on the Utah family sample. Herein, we tested the 19 variants individually and in pairs for an effect on T2D...
Topics
- Age Factors
- Analysis of Variance
- Apolipoprotein A-II
- Calcium-Binding Proteins
- Calsequestrin
- Chromosomes, Human, Pair 1
- Diabetes Mellitus, Type 2
- Dual-Specificity Phosphatases
- Female
- Genetic Predisposition to Disease
- Humans
- Linkage Disequilibrium
- Logistic Models
- Male