Power of linkage disequilibrium mapping to detect a quantitative trait locus (QTL) in selected samples of unrelated individuals.

doi:10.1046/j.1529-8817.2003.00058.x

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Article

Power of linkage disequilibrium mapping to detect a quantitative trait locus (QTL) in selected samples of unrelated individuals.

Annals of human genetics - 1 Nov 2003

Tenesa A, Knott S A, Carothers A D, Visscher P M

Abstract excerpt

We considered a strategy to map quantitative trait loci (QTLs) using linkage disequilibrium (LD) when the QTL and marker locus were multiallelic. The strategy involved phenotyping a large number of unrelated individuals and genotyping only selected individuals from the two tails of the trait distribution. Power to detect trait-marker association was assessed as a function of the number of QTL and marker alleles....

Topics

Chromosome Mapping
Gene Frequency
Genotype
Humans
Linkage Disequilibrium
Models, Genetic
Phenotype
Quantitative Trait Loci
Research Design

Source

Open in PubMed

Identifiers

PMID: 14641243
DOI: 10.1046/j.1529-8817.2003.00058.x

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