Regressive logistic models for familial diseases: a formulation assuming an underlying liability model.

Abstract excerpt

Statistical models have been developed to delineate the major-gene and non-major-gene factors accounting for the familial aggregation of complex diseases. The mixed model assumes an underlying liability to the disease, to which a major gene, a multifactorial component, and random environment contribute independently. Affection is defined by a threshold on the liability scale. The regressive logistic models assume...

Topics

• Environment
• Genes, Dominant
• Genetic Diseases, Inborn
• Genotype
• Logistic Models
• Mathematics
• Nuclear Family
• Phenotype
• Regression Analysis