Article
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.
PloS one - 1 Jan 2008
Keating Brendan J, Tischfield Sam, Murray Sarah S, Bhangale Tushar, Price Thomas S, Glessner Joseph T, Galver Luana, Barrett Jeffrey C, Grant Struan F A, Farlow Deborah N, Chandrupatla Hareesh R, Hansen Mark, Ajmal Saad, Papanicolaou George J, Guo Yiran, Li Mingyao, Derohannessian Stephanie, de Bakker Paul I W, Bailey Swneke D, Montpetit Alexandre, Edmondson Andrew C, Taylor Kent, Gai Xiaowu, Wang Susanna S, Fornage Myriam, Shaikh Tamim, Groop Leif, Boehnke Michael, Hall Alistair S, Hattersley Andrew T, Frackelton Edward, Patterson Nick, Chiang Charleston W K, Kim Cecelia E, Fabsitz Richard R, Ouwehand Willem, Price Alkes L, Munroe Patricia, Caulfield Mark, Drake Thomas, Boerwinkle Eric, Reich David, Whitehead A Stephen, Cappola Thomas P, Samani Nilesh J, Lusis A Jake, Schadt Eric, Wilson James G, Koenig Wolfgang, McCarthy Mark I, Kathiresan Sekar, Gabriel Stacey B, Hakonarson Hakon, Anand Sonia S, Reilly Muredach, Engert James C, Nickerson Deborah A, Rader Daniel J, Hirschhorn Joel N, Fitzgerald Garret A
Abstract excerpt
A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS). True complex disease-associated loci often exert modest effects, so their delineation currently requires integration of diverse phenotypic data from large studies to ensure robust...
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