Strategies for Enriching Variant Coverage in Candidate Disease Loci on a Multiethnic Genotyping Array.

doi:10.1371/journal.pone.0167758

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Article

Strategies for Enriching Variant Coverage in Candidate Disease Loci on a Multiethnic Genotyping Array.

PloS one - 1 Jan 2016

Bien Stephanie A, Wojcik Genevieve L, Zubair Niha, Gignoux Christopher R, Martin Alicia R, Kocarnik Jonathan M, Martin Lisa W, Buyske Steven, Haessler Jeffrey, Walker Ryan W, Cheng Iona, Graff Mariaelisa, Xia Lucy, Franceschini Nora, Matise Tara, James Regina, Hindorff Lucia, Le Marchand Loic, North Kari E, Haiman Christopher A, Peters Ulrike, Loos Ruth J F, Kooperberg Charles L, Bustamante Carlos D, Kenny Eimear E, Carlson Christopher S

Abstract excerpt

Investigating genetic architecture of complex traits in ancestrally diverse populations is imperative to understand the etiology of disease. However, the current paucity of genetic research in people of African and Latin American ancestry, Hispanic and indigenous peoples in the United States is likely to exacerbate existing health disparities for many common diseases. The Population Architecture using Genomics...

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PMID: 27973554
DOI: 10.1371/journal.pone.0167758
PMCID: PMC5156387

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