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Article

Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein.

Glycobiology - 1 Mar 2009

Kraschnefski Mark J, Bugarcic Andrea, Fleming Fiona E, Yu Xing, von Itzstein Mark, Coulson Barbara S, Blanchard Helen

Abstract excerpt

The rotavirus spike protein VP4 mediates attachment to host cells and subsequent membrane penetration. The VP8(*) domain of VP4 forms the spike tips and is proposed to recognize host-cell surface glycans. For sialidase-sensitive rotaviruses such as rhesus (RRV), this recognition involves terminal...

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Source

Identifiers

PMID: 18974199
DOI: 10.1093/glycob/cwn119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18974199-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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